Definitive radiotherapy plus regional hyperthermia with or without chemotherapy for superior sulcus tumors (from Lung cancer)

Lung Cancer. 2011 Mar;71(3):338-43. doi: 10.1016/j.lungcan.2010.06.007. Epub 2010 Jul 8.

Definitive radiotherapy plus regional hyperthermia with or without chemotherapy for superior sulcus tumors (from Lung cancer): a 20-year, single center experience.

Moon SDOhguri TImada HYahara KYamaguchi SHanagiri TYasumoto KYatera KMukae HTerashima HKorogi Y.

Source

Department of Radiology, University of Occupational and Environmental Health, Yahatanishi-ku, Kitakyushu, Japan.

Abstract

PURPOSE:

To assess the efficacy and toxicity of definitive radiotherapy (RT) plus regional hyperthermia (HT) in treating superior sulcus tumors (SSTs), and to identify predictors of positive outcomes.

METHODS AND MATERIALS:

Twenty-four patients with SSTs treated with definitive RT plus regional HT were retrospectively analyzed. The median total dose of RT was 70 Gy. All patients were treated with an 8-MHz RF-capacitive heating device. Twelve of 24 (50%) patients also underwent chemotherapy. Those with either subcutaneous fat measuring 2.5 cm or greater, or any other serious complications did not undergo this therapy.

RESULTS:

Overall survival, local control, and distant metastasis-free survival rates at 3 years were 47%, 55%, and 71%, respectively. Chemotherapy and younger age (<65 years) were significant predictors of the overall survival rate. Clinical stage (IIB) was a statistically significant prognostic indicator for local control survival rate. Toxicities were mild, with Grade 3 dermatitis seen in one patient.

CONCLUSIONS:

Definitive RT plus regional HT with chemotherapy may be a promising treatment for SSTs. The results justify further evaluation with detailed treatment protocols in a large number of patients.

Moon-2011-Definitive Radiotherapy Plus Regiona
Moon-2011-Definitive Radiotherapy Plus Regiona
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