Allogenic hematopoietic stem cell transplantation (allo-HSCT) is a curative treatment for hematological disorders but often results in micronutrients deficiency and complications. Vitamin C, a potent antioxidant, may improve endothelial function, tissue protection, and immune recovery. A February 2026 triple blind study evaluated the effects of early high-dose vitamin C supplementation on plasma vitamin C levels and post-HSCT complications. As a result vitamin C effectively corrected plasma levels, and trends toward reduced complications were observed such as in GVRD and mouth sores. The treatment was well tolerated and demonstrated safety.
https://link.springer.com/article/10.1007/s00520-026-10434-2
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