A single dose of intravenous vitamin C during surgery or as part of the anesthesia process, for total hip replacement resulted in less opiate use, improvement in pain scores, reduction in inflammation, and increased range of motion. The authors felt that it would be advisable in future to examine daily administration of intravenous vitamin C versus looking at the studied 24 hour postoperatively. No signs of problems or interference was reported in this double-blind, placebo-controlled, randomized trial of a 100 patients.
https://josr-online.biomedcentral.com/articles/10.1186/s13018-024-05193-x
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